YOD1 antibody (N-Term)

Catalog No. ABIN2790891

Product Details anti-YOD1 Antibody

Target: YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YOD1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VPQSEAGTKA GPAGGRPADT MWRVRCKAKG GTHLLQGLSS RTRLRELQGQ

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against Yod1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Yod1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for YOD1

Target: YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))

Alternative Name: Yod1 (YOD1 Products)

Synonyms: DUBA8 antibody, OTUD2 antibody, PRO0907 antibody, hshin7 antibody, wu:fe01a10 antibody, zgc:112182 antibody, 9930028C20Rik antibody, Hshin7 antibody, YOD1 deubiquitinase antibody, YOD1 deubiquitinase L homeolog antibody, YOD1 antibody, Yod1 antibody, yod1.L antibody, yod1 antibody

Background: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Yod1 may act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Yod1 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. It is able to cleave both polyubiquitin and di-ubiquitin.
Alias Symbols: 9930028C20Rik, Hshin7
Protein Size: 343

Molecular Weight: 37 kDa

Gene ID: 226418

NCBI Accession: NM_178691, NP_848806

UniProt: Q8CB27

Pathways: ER-Nucleus Signaling