TFAP2A antibody (C-Term)
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- Target See all TFAP2A Antibodies
- TFAP2A (Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Guinea Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TFAP2A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- NLISHGFGSP AVCAAVTALQ NYLTEALKAM DKMYLSNNPN SHTDNNAKSS
- Cross-Reactivity
- Cow (Bovine), Chicken, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
- Predicted Reactivity
- Dog: 92%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%
- Characteristics
- This is a rabbit polyclonal antibody against TFAP2A. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human TFAP2A
- Top Product
- Discover our top product TFAP2A Primary Antibody
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- Application Notes
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WB Suggested Anti-TFAP2A Antibody Titration: 1.25 µg/mL
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator. - Comment
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Antigen size: 437 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TFAP2A (Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A))
- Alternative Name
- AP-2 alpha / TFAP2A (TFAP2A Products)
- Synonyms
- TFAP2A antibody, Ap-2 antibody, AP-2 antibody, AP-2alpha antibody, AP2TF antibody, BOFS antibody, TFAP2 antibody, ap2 antibody, xap2 antibody, XAP-2 antibody, ap2tf antibody, tfap2 antibody, ap-2alpha antibody, tfap2alpha antibody, cb93 antibody, fb83f04 antibody, fc31a07 antibody, wu:fb83f04 antibody, wu:fc31a07 antibody, tfap2a-a antibody, tcfap2a antibody, ap2a antibody, AP2alpha antibody, Ap2 antibody, Ap2tf antibody, Tcfap2a antibody, AP2 antibody, transcription factor AP-2 alpha antibody, transcription factor AP-2 antibody, tto transcription factor AP-2 alpha antibody, to transcription factor AP-2 alpha L homeolog antibody, to transcription factor AP-2 alpha S homeolog antibody, Transcription factor AP-2 alpha antibody, transcription factor AP-2, alpha antibody, TFAP2A antibody, LOC100302602 antibody, tfap2a antibody, tfap2a.L antibody, tfap2a.S antibody, ap2a antibody, Tfap2a antibody
- Background
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TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicleAP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters.[supplied by OMIM].
Alias Symbols: AP-2, BOFS, AP2TF, TFAP2, AP-2alpha
Protein Interaction Partner: MKRN3, GSTO2, KCTD15, SUMO1, HECW2, SP1, BAG3, RB1, UBC, DAB2, Fcho2, EPAS1, SRA1, EPS15, KCTD1, EPN1, SH3BP4, UBE2I, AURKA, BRCA1, DNMT3A, ELAVL1, SUMO4, SUMO2, NPM1, YY1, PPARG, EPN2, CITED4, LDLRAP1, CITED2, EP300, MAGI1, WWP2, WWP1, HIP1, CASP6, CASP3
Protein Size: 437 - Molecular Weight
- 48 kDa
- Gene ID
- 7020
- NCBI Accession
- NM_003220, NP_003211
- UniProt
- P05549
- Pathways
- Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Response to Water Deprivation, Sensory Perception of Sound, Tube Formation, Embryonic Body Morphogenesis, Brown Fat Cell Differentiation, Lipid Metabolism
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