ABCC5 antibody (Center)

Catalog No. ABIN2793440

Product Details anti-ABCC5 Antibody

Target: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Binding Specificity: AA 625-652, Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: Rabbit Anti-Human ABCC5 (Center) Antibody

Immunogen: This ABCC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 625-652 amino acids from the Central region of human ABCC5.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50Western blot analysis of ABCC5 Antibody (Center) . FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for ABCC5

Target: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Alternative Name: ABCC5 (ABCC5 Products)

Synonyms: ABC33 antibody, EST277145 antibody, MOAT-C antibody, MOATC antibody, MRP5 antibody, SMRP antibody, pABC11 antibody, 2900011L11Rik antibody, AI132311 antibody, Abcc5a antibody, Abcc5b antibody, Mrp5 antibody, abc33 antibody, abcc5 antibody, moat-c antibody, moatc antibody, mrp5 antibody, pabc11 antibody, smrp antibody, ATP binding cassette subfamily C member 5 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 5 antibody, ATP binding cassette subfamily C member 5 L homeolog antibody, ABCC5 antibody, Abcc5 antibody, abcc5.L antibody

Background:

Target Description: ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs,6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.

Gene Symbol: ABCC5

Molecular Weight: 160660 Da

Gene ID: 10057

UniProt: O15440

Pathways: Glycosaminoglycan Metabolic Process