SMAD2 antibody (SMAD, Mothers Against DPP Homolog 2)

Details for Product anti-SMAD2 Antibody No. ABIN2801941, Supplier: Log in to see
Antigen
  • JV18
  • JV18-1
  • MADH2
  • MADR2
  • hMAD-2
  • hSMAD2
  • jv18
  • Xmad2
  • madh2
  • madr2
  • XSmad2
  • hmad-2
  • hsmad2
  • jv18-1
  • smad-2
  • fj43c06
  • wu:fj43c06
  • 7120426M23Rik
  • Madh2
  • Madr2
  • Smad-2
  • mMad2
  • MAD homolog 2
  • Mothers against DPP homolog 2
  • SMAD 2
  • Smad2
  • SMAD family member 2
  • SMAD family member 2-Z
  • SMAD family member 2 S homeolog
  • SMAD2
  • SMAD2Z
  • smad2
  • smad2.S
  • Smad2
Alternatives
anti-Human SMAD2 antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Meriones)
458
266
234
30
22
18
18
17
13
11
11
9
7
5
5
3
2
1
1
1
1
Host
Rabbit
399
58
19
Clonality
Polyclonal
Conjugate
This SMAD2 antibody is un-conjugated
18
13
12
7
7
7
2
2
2
2
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
413
207
119
90
58
30
28
27
26
25
21
6
5
4
3
3
1
Options
Supplier
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Isotype IgG
Plasmids, Primers & others Plasmids, Primers & others SMAD2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Smad2 (SMAD2 Antibody Abstract)
Background Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Synonyms: Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2
Molecular Weight 52306 Da
Gene ID 4087
UniProt Q15796
Pathways Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
Application Notes WB - 1:1000
Restrictions For Research Use only
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) antibody (ABIN2801941) anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) antibody
Product cited in: Liu, Pouponnot, Massagué: "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes." in: Genes & development, Vol. 11, Issue 23, pp. 3157-67, 1998 (PubMed).

Takenoshita, Mogi, Nagashima, Yang, Yagi, Hanyu, Nagamachi, Miyazono, Hagiwara: "Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway." in: Genomics, Vol. 48, Issue 1, pp. 1-11, 1998 (PubMed).

Zhang, Feng, We, Derynck: "Receptor-associated Mad homologues synergize as effectors of the TGF-beta response." in: Nature, Vol. 383, Issue 6596, pp. 168-72, 1996 (PubMed).

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