PCDHB14 antibody (AA 551-650) (Alexa Fluor 594)

Catalog No. ABIN2805143

Product Details anti-PCDHB14 Antibody (Alexa Fluor 594)

Target: PCDHB14 (Protocadherin beta 14 (PCDHB14))

Binding Specificity: AA 551-650

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHB14 antibody is conjugated to Alexa Fluor 594

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PCDHB14

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PCDHB14

Target: PCDHB14 (Protocadherin beta 14 (PCDHB14))

Alternative Name: PCDHB14 (PCDHB14 Products)

Synonyms: PCDH-BETA14 antibody, 2210006M07Rik antibody, Pcdhb17 antibody, PcdhbN antibody, PCDHB14 antibody, protocadherin beta 14 antibody, protocadherin beta-14 antibody, PCDHB14 antibody, Pcdhb14 antibody, LOC487175 antibody, LOC100061546 antibody, LOC100353156 antibody

Background:

Synonyms: MGC120065, PCDBE_HUMAN, PCDH beta14, PCDH-beta-14, PCDHB 14, PCDHB14, Protocadherin beta 14, Protocadherin beta-14.

Background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHB14 (Protocadherin beta 14) is a 798 amino acid protein that is one of 16 proteins in the protocadherin beta cluster. Unlike the alpha and gamma gene clusters whos genes are spliced to downstream constant region exons during transcription, members of the beta cluster (such as PCDHB14) do not use constant-region exons to produce mRNAs. As a result, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. Localized to the cell membrane, PCDHB14 is a single-pass type I membrane protein that contains six cadherin domains.