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AP2A2 antibody (AA 21-150) (Alexa Fluor 594)

AP2A2 Reactivity: Human, Mouse WB, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 594
Catalog No. ABIN2809664
  • Target See all AP2A2 Antibodies
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    Binding Specificity
    • 14
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-150
    Reactivity
    • 41
    • 28
    • 12
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 40
    • 1
    Rabbit
    Clonality
    • 41
    Polyclonal
    Conjugate
    • 16
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AP2A2 antibody is conjugated to Alexa Fluor 594
    Application
    • 33
    • 13
    • 12
    • 12
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Specificity
    Based on the similarity among the Alpha2-Adaptin proteins, this antibody will bind both AP2A1 and AP2A2.
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Cow,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human AP2A2
    Isotype
    IgG
    Top Product
    Discover our top product AP2A2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    Alternative Name
    alpha2 Adaptin (AP2A2 Products)
    Synonyms
    MGC99219 antibody, ADTAB antibody, CLAPA2 antibody, HIP-9 antibody, HIP9 antibody, HYPJ antibody, 2410074K14Rik antibody, AF006990 antibody, AW146353 antibody, Adtab antibody, C78001 antibody, L25 antibody, adaptor related protein complex 2 alpha 2 subunit antibody, adaptor related protein complex 2 alpha 2 subunit L homeolog antibody, adaptor-related protein complex 2, alpha 2 subunit antibody, AP2A2 antibody, ap2a2.L antibody, Ap2a2 antibody
    Background

    Synonyms: AP-2 complex subunit alpha-2, 100 kDa coated vesicle protein C, Adaptor protein complex AP-2 subunit alpha-2, Adaptor-related protein complex 2 subunit alpha-2, Alpha-adaptin C, Alpha2-adaptin, Clathrin assembly protein complex 2 alpha-C large chain, Huntingtin yeast partner J, Huntingtin-interacting protein 9, HIP-9, Huntingtin-interacting protein J, Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit, AP2A2, ADTAB, CLAPA2, AP-2 complex subunit alpha-1, 100 kDa coated vesicle protein A, Adaptor protein complex AP-2 subunit alpha-1, Adaptor-related protein complex 2 subunit alpha-1, Alpha-adaptin A, Alpha1-adaptin, Clathrin assembly protein complex 2 alpha-A large chain, Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit, AP2A1, ADTAA, CLAPA1

    Background: Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

    Gene ID
    161
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome
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