PTPN23 antibody (AA 1501-1636) (Alexa Fluor 594)

Catalog No. ABIN2814234

Product Details anti-PTPN23 Antibody (Alexa Fluor 594)

Target: PTPN23 (Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23))

Binding Specificity: AA 1501-1636

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN23 antibody is conjugated to Alexa Fluor 594

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HDPTP

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PTPN23

Target: PTPN23 (Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23))

Alternative Name: HDPTP (PTPN23 Products)

Synonyms: HD-PTP antibody, HDPTP antibody, PTP-TD14 antibody, AI462446 antibody, Ptp-Td14 antibody, ptp23b antibody, si:dkeyp-114f9.2 antibody, protein tyrosine phosphatase, non-receptor type 23 antibody, protein tyrosine phosphatase, non-receptor type 23, b antibody, PTPN23 antibody, Ptpn23 antibody, ptpn23b antibody

Background:

Synonyms: DKFZP564F0923, EC 3.1.3.48, HD PTP, HD-PTP, HDPTP, His domain containing protein tyrosine phosphatase, His domain protein tyrosine phosphatase, His domain-containing protein tyrosine phosphatase, KIAA1471, Protein tyrosine phosphatase non receptor type 23, protein tyrosine phosphatase non-receptor type 23, Protein tyrosine phosphatase TD 14, protein tyrosine phosphatase TD14, PTN23_HUMAN, PTP TD14, PTP-TD14, PTPN 23, PTPN23, Tyrosine protein phosphatase non receptor type 23, Tyrosine-protein phosphatase non-receptor type 23.

Background: HD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.

Gene ID: 25930