IFNAR1 antibody (AA 162-188)

Catalog No. ABIN2842330

Product Details anti-IFNAR1 Antibody

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Binding Specificity: AA 162-188

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNAR1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IFNAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-188 amino acids of human IFNAR1.

Clone: RB21945

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:1000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-IFNAR1 antibody (ABIN2842330)

Dendrou, Cortes, Shipman, Evans, Attfield, Jostins, Barber, Kaur, Kuttikkatte, Leach, Desel, Faergeman, Cheeseman, Neville, Sawcer, Compston, Johnson, Everett, Bell, Karpe, Ultsch, Eigenbrot, McVean et al.: "Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. ..." in: Science translational medicine, Vol. 8, Issue 363, pp. 363ra149, (2017) (PubMed).

Target Details for IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Alternative Name: IFNAR1 (IFNAR1 Products)

Synonyms: ifnar1 antibody, IFNAR1 antibody, CD118 antibody, Ifar antibody, Ifnar antibody, Ifrc antibody, Infar antibody, AVP antibody, IFN-alpha-REC antibody, IFNAR antibody, IFNBR antibody, IFRC antibody, IFN-R-1 antibody, interferon alpha and beta receptor subunit 1 antibody, interferon-alpha/beta receptor alpha chain-like antibody, interferon (alpha and beta) receptor 1 antibody, interferon alpha/beta receptor 1 antibody, IFNAR1 antibody, ifnar1 antibody, Ifnar1 antibody, LOC609830 antibody

Background: IFNAR1 is the receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha-and beta-subunits themselves.

Molecular Weight: 63525

Gene ID: 3454

NCBI Accession: NP_000620

UniProt: P17181

Pathways: JAK-STAT Signaling, Hepatitis C