ADAMTS18 antibody (C-Term)

Catalog No. ABIN2842553

Product Details anti-ADAMTS18 Antibody

Target: ADAMTS18 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18))

Binding Specificity: AA 1066-1095, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAMTS18 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ADAMTS18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1066-1095 amino acids from the C-terminal region of human ADAMTS18.

Clone: RB22477

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ADAMTS18 antibody (ABIN2842553)

Reddy, Fernandes, Deshpande, Weisberg, Inguilizian, Abdel-Wahab, Kung, Levine, Griffin, Sattler: "The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity." in: Leukemia, Vol. 26, Issue 3, pp. 481-9, (2012) (PubMed).

Aldahmesh, Khan, Mohamed, Alkuraya, Ahmed, Bobis, Al-Mesfer, Alkuraya: "Identification of ADAMTS18 as a gene mutated in Knobloch syndrome." in: Journal of medical genetics, Vol. 48, Issue 9, pp. 597-601, (2011) (PubMed).

Target Details for ADAMTS18

Target: ADAMTS18 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18))

Alternative Name: ADAMTS18 (ADAMTS18 Products)

Synonyms: 9630038L21 antibody, ADAMTS21 antibody, E130314N14Rik antibody, KNO2 antibody, RGD1560118 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 18 antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 18 antibody, Adamts18 antibody, ADAMTS18 antibody

Background: ADAMTS18 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This protein has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor.

Molecular Weight: 135167

Gene ID: 170692

NCBI Accession: NP_955387

UniProt: Q8TE60