CYP11B2 antibody (AA 120-147)

Catalog No. ABIN2844780

Product Details anti-CYP11B2 Antibody

Target: CYP11B2 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2))

Binding Specificity: AA 120-147

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP11B2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CYP11B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-147 amino acids from the Central region of human CYP11B2.

Clone: RB16930

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:10~50. IHC-P: 1:25. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for CYP11B2

Target: CYP11B2 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2))

Alternative Name: CYP11B2 (CYP11B2 Products)

Synonyms: ALDOS antibody, CPN2 antibody, CYP11B antibody, CYP11BL antibody, CYPXIB2 antibody, P-450C18 antibody, P450C18 antibody, P450aldo antibody, Cpn2 antibody, Cyp11b antibody, Cyp11b-2 antibody, Cp45as antibody, Cyp11b3 antibody, RNCP45AS antibody, cytochrome P450 family 11 subfamily B member 2 antibody, cytochrome P450, family 11, subfamily b, polypeptide 2 antibody, aldosterone synthase antibody, cytochrome P450, family 11, subfamily B, polypeptide 2 antibody, cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 antibody, CYP11B2 antibody, Cyp11b2 antibody

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.

Molecular Weight: 57560

Gene ID: 1585

NCBI Accession: NP_000489

UniProt: P19099

Pathways: ACE Inhibitor Pathway, Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones, C21-Steroid Hormone Metabolic Process, Feeding Behaviour