TRAF3 antibody (C-Term)

Catalog No. ABIN2846822

Product Details anti-TRAF3 Antibody

Target: TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))

Binding Specificity: AA 490-517, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TRAF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-517 amino acids from the C-terminal region of human TRAF3.

Clone: RB22535

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: TRAF3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for TRAF3

Target: TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))

Alternative Name: TRAF3 (TRAF3 Products)

Synonyms: CAP-1 antibody, CAP1 antibody, CD40bp antibody, CRAF1 antibody, IIAE5 antibody, LAP1 antibody, AI528849 antibody, T-BAM antibody, amn antibody, TNF receptor associated factor 3 antibody, TNF receptor-associated factor 3 antibody, Tnf receptor-associated factor 3 antibody, TRAF3 antibody, Traf3 antibody

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Molecular Weight: 64490

Gene ID: 7187

NCBI Accession: NP_001186356, NP_003291, NP_663777, NP_663778

UniProt: Q13114

Pathways: NF-kappaB Signaling, Apoptosis, TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades