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NR2F6 antibody (C-Term)

NR2F6 Reactivity: Human WB, IHC (p), ChIP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2854676
  • Target See all NR2F6 Antibodies
    NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))
    Binding Specificity
    • 15
    • 8
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 54
    • 22
    • 22
    • 12
    • 9
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 49
    • 4
    • 1
    Rabbit
    Clonality
    • 51
    • 3
    Polyclonal
    Conjugate
    • 31
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NR2F6 antibody is un-conjugated
    Application
    • 34
    • 27
    • 15
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Chromatin Immunoprecipitation (ChIP)
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Rabbit Polyclonal antibody to NR2F6 (nuclear receptor subfamily 2, group F, member 6)
    NR2F6 antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human NR2F6. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product NR2F6 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))
    Alternative Name
    nuclear receptor subfamily 2 group F member 6 (NR2F6 Products)
    Synonyms
    EAR-2 antibody, EAR2 antibody, ERBAL2 antibody, AV090102 antibody, COUP-TF3 antibody, Erbal2 antibody, COUP(II) antibody, NR2F6 antibody, couptf2 antibody, fc94g11 antibody, wu:fc94g11 antibody, zgc:77259 antibody, ear-2 antibody, ear2 antibody, erbal2 antibody, nr2f6l antibody, wu:fc72d04 antibody, zgc:77260 antibody, nuclear receptor subfamily 2 group F member 6 antibody, nuclear receptor subfamily 2, group F, member 6 antibody, nuclear receptor subfamily 2, group F, member 6a antibody, nuclear receptor subfamily 2 group F member 6 L homeolog antibody, nuclear receptor subfamily 2, group F, member 6b antibody, NR2F6 antibody, Nr2f6 antibody, nr2f6a antibody, nr2f6.L antibody, nr2f6 antibody, nr2f6b antibody
    Background
    Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock, is required early in the development of the locus coeruleus (LC).

    Cellular Localization: Nucleus
    Molecular Weight
    43 kDa
    Gene ID
    2063
    UniProt
    P10588
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Photoperiodism
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