LTBP4 antibody (N-Term)

Catalog No. ABIN2855142

Product Details anti-LTBP4 Antibody

Target: LTBP4 (Latent Transforming Growth Factor beta Binding Protein 4 (LTBP4))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LTBP4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit Polyclonal antibody to LTBP4 (latent transforming growth factor beta binding protein 4)
LTBP4 antibody [N1N2], N-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human LTBP4. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Mouse brain , Positive Control: Mouse brain

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.07 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for LTBP4

Target: LTBP4 (Latent Transforming Growth Factor beta Binding Protein 4 (LTBP4))

Alternative Name: latent transforming growth factor beta binding protein 4 (LTBP4 Products)

Synonyms: ARCL1C antibody, LTBP-4 antibody, LTBP4L antibody, LTBP4S antibody, 2310046A13Rik antibody, latent transforming growth factor beta binding protein 4 antibody, LTBP4 antibody, ltbp4 antibody, Ltbp4 antibody

Background: Transforming growth factor-beta, or TGFB (see TGFB1, MIM 190180), remains biologically latent after secretion, blocked from activity by its N-terminal propeptide (the latency-associated peptide, or LAP). TGFB is activated by its dissociation from LAP. The latent form of TGFB is secreted in association with a latent TGFB-binding protein, or LTBP (see LTBP1, MIM 150390), and assembled into the extracellular matrix. LTBPs are mainly composed of epidermal growth factor (EGF, MIM 131530)-like repeats and protein domains with 8-cysteine repeats, both of which are also found in fibrillins (e.g., MIM 134797). See Oklu and Hesketh (2000) [PubMed 11104663] for a review of the LTBP gene family.[supplied by OMIM]

Cellular Localization: Secreted , extracellular space , extracellular matrix

Molecular Weight: 173 kDa

Gene ID: 8425

UniProt: Q8N2S1

Pathways: Hormone Transport, Growth Factor Binding