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RAN antibody

RAN Reactivity: Human IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2855298
  • Target See all RAN Antibodies
    RAN (RAN, Member RAS Oncogene Family (RAN))
    Reactivity
    • 87
    • 44
    • 42
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 80
    • 5
    • 2
    Rabbit
    Clonality
    • 81
    • 5
    Polyclonal
    Conjugate
    • 42
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RAN antibody is un-conjugated
    Application
    • 65
    • 34
    • 28
    • 26
    • 26
    • 17
    • 11
    • 9
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human
    Characteristics
    Rabbit Polyclonal antibody to RAN (RAN, member RAS oncogene family)
    RAN antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human RAN. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product RAN Primary Antibody
  • Application Notes
    ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    RAN (RAN, Member RAS Oncogene Family (RAN))
    Alternative Name
    RAN, member RAS oncogene family (RAN Products)
    Synonyms
    ARA24 antibody, Gsp1 antibody, TC4 antibody, ran antibody, ara24 antibody, gsp1 antibody, ran-1 antibody, tc4 antibody, RAN antibody, RANP1 antibody, AAF30287 antibody, CG1404 antibody, Dmel\CG1404 antibody, Ran antibody, dran antibody, l(1)G0075 antibody, ran10A antibody, fc16b04 antibody, wu:fc16b04 antibody, RAN, member RAS oncogene family antibody, RAN, member RAS oncogene family S homeolog antibody, CG1404 gene product from transcript CG1404-RC antibody, RAN antibody, Ran antibody, ran.S antibody, ran antibody
    Background
    RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

    Cellular Localization: Nucleus , Cytoplasm , Melanosome
    Molecular Weight
    24 kDa
    Gene ID
    5901
    UniProt
    P62826
    Pathways
    Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
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