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ACVR2B antibody (Center)

ACVR2B Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2856085
  • Target See all ACVR2B Antibodies
    ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
    Binding Specificity
    • 15
    • 9
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 76
    • 31
    • 31
    • 11
    • 10
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 74
    • 7
    • 3
    Rabbit
    Clonality
    • 79
    • 5
    Polyclonal
    Conjugate
    • 37
    • 13
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ACVR2B antibody is un-conjugated
    Application
    • 79
    • 28
    • 27
    • 13
    • 13
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Rat (Rattus), Pig (Porcine)
    Cross-Reactivity (Details)
    Rat (100 %), Pig (100 %)
    Characteristics
    Rabbit Polyclonal antibody to Activin Receptor Type IIB (activin A receptor, type IIB)
    Activin Receptor Type IIB antibody [N1C1]
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human Activin Receptor Type IIB. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product ACVR2B Primary Antibody
  • Application Notes
    Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*
    Comment

    Positive Control: U87-MG

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
    Alternative Name
    Activin Receptor Type IIB (ACVR2B Products)
    Synonyms
    ACVR2B antibody, XAR1 antibody, actr-iib antibody, actriib antibody, ACTRIIB antibody, ActR-IIB antibody, HTX4 antibody, ActRIIB antibody, actr2b antibody, actrIIb antibody, wu:fj97d11 antibody, activin A receptor type 2B antibody, activin A receptor type 2B L homeolog antibody, activin A receptor type 2Ba antibody, activin receptor IIB antibody, ACVR2B antibody, acvr2b antibody, acvr2b.L antibody, Acvr2b antibody, acvr2ba antibody
    Background
    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

    Molecular Weight
    58 kDa
    Gene ID
    93
    Pathways
    Hormone Transport, Cancer Immune Checkpoints
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