TP53I3 antibody

Catalog No. ABIN2856195

Product Details anti-TP53I3 Antibody

Target: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TP53I3 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to PIG3 (tumor protein p53 inducible protein 3)
PIG3 antibody [N2C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human PIG3. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: A549

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for TP53I3

Target: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Alternative Name: tumor protein p53 inducible protein 3 (TP53I3 Products)

Synonyms: MGC82892 antibody, MGC146409 antibody, PIG3 antibody, tumor protein p53 inducible protein 3 antibody, tumor protein p53 inducible protein 3 S homeolog antibody, Tp53I3 antibody, quinone oxidoreductase PIG3 antibody, TP53I3 antibody, tp53i3.S antibody, tp53i3 antibody, tp53I3 antibody

Background: The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.

Molecular Weight: 36 kDa

Gene ID: 9540

UniProt: Q53FA7

Pathways: p53 Signaling