CBFA2T2 antibody (C-Term)
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- Target See all CBFA2T2 Antibodies
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CBFA2T2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Cross-Reactivity
- Mouse (Murine), Chicken, Rat (Rattus)
- Cross-Reactivity (Details)
- Mouse (95 %), Chicken (80 %), Rat (95 %)
- Characteristics
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Rabbit polyclonal antibody to CBFA2T2 (core-binding factor, runt domain, alpha subunit 2, translocated to, 2)
MTGR1 antibody [C1C3] - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the C-terminus region of human MTGR1. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product CBFA2T2 Primary Antibody
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- Application Notes
- Suggested dilution Reference ICC/IF 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* Western blot1:500-1:3000*
- Comment
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Positive Control: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
- Alternative Name
- CBFA2T2 (CBFA2T2 Products)
- Synonyms
- MTGR1 antibody, A430091M07 antibody, C330013D05Rik antibody, Cbfa2t2h antibody, EHT antibody, ZMYND3 antibody, p85 antibody, XETOR antibody, cbfa2t2-a antibody, CBFA2/RUNX1 translocation partner 2 antibody, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) antibody, CBFA2/RUNX1 translocation partner 2 L homeolog antibody, Cbfa2t2 antibody, CBFA2T2 antibody, cbfa2t2.L antibody
- Background
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In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Cellular Localization: Nucleus - Molecular Weight
- 67 kDa
- Gene ID
- 9139
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