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ZC3H12A antibody

KO Validated ZC3H12A Reactivity: Human WB, IHC, FACS, IF, IP, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2856778
  • Target See all ZC3H12A Antibodies
    ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))
    Reactivity
    • 40
    • 18
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 39
    • 1
    Rabbit
    Clonality
    • 39
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ZC3H12A antibody is un-conjugated
    Application
    • 35
    • 21
    • 17
    • 13
    • 13
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificity
    Knockdown/Knockout validation was supported by references (PMID:27322373)
    Cross-Reactivity
    Human
    Characteristics
    Rabbit Polyclonal antibody to ZC3H12A (zinc finger CCCH-type containing 12A)
    ZC3H12A antibody [N3C3]
    Purification
    Purified by antigen-affinity chromatography.
    Grade
    KO Validated
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human ZC3H12A. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product ZC3H12A Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Validatio: KO/KD, Orthogonal

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.8 mg/mL
    Buffer
    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Li, Huang, Huang, Li, Falcon, Soutar, Bornancin, Jiang, Xin, Fu: "Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression." in: Cellular signalling, Vol. 50, pp. 1-8, (2019) (PubMed).

    Li, Huang, Huang, He, Lei, Saaoud, Yu, Melnick, Kumar, Papasian, Fan, Fu: "Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury." in: Signal transduction and targeted therapy, Vol. 2, pp. 17066, (2017) (PubMed).

    Skalniak, Dziendziel, Jura: "MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB." in: Molecular and cellular biochemistry, Vol. 395, Issue 1-2, pp. 253-63, (2015) (PubMed).

    Skalniak, Koj, Jura: "Proteasome inhibitor MG-132 induces MCPIP1 expression." in: The FEBS journal, Vol. 280, Issue 11, pp. 2665-74, (2013) (PubMed).

    Qi, Liang, She, Cai, Wang, Lei, Stallcup, Fu: "MCP-induced protein 1 suppresses TNFalpha-induced VCAM-1 expression in human endothelial cells." in: FEBS letters, Vol. 584, Issue 14, pp. 3065-72, (2010) (PubMed).

  • Target
    ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))
    Alternative Name
    zinc finger CCCH-type containing 12A (ZC3H12A Products)
    Synonyms
    CGA antibody, MCPIP antibody, MCPIP1 antibody, RP3-423B22.1 antibody, dJ423B22.1 antibody, BC036563 antibody, Mcpip1 antibody, RGD1306776 antibody, chromogranin A antibody, zinc finger CCCH-type containing 12A antibody, zinc finger CCCH type containing 12A antibody, CHGA antibody, ZC3H12A antibody, Zc3h12a antibody
    Background
    ZC3H12A is an MCP1 (CCL2, MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM]

    Cellular Localization: Cytoplasm (By similarity) , Nucleus
    Molecular Weight
    66 kDa
    Gene ID
    80149
    UniProt
    Q5D1E8
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation
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