Paternally Expressed 10 (PEG10) (AA 1-120) antibody

Details for Product No. ABIN2869375, Supplier: Log in to see
Antigen
  • EDR
  • HB-1
  • MEF3L
  • Mar2
  • Mart2
  • RGAG3
  • AA407948
  • Edr
  • MyEF-3
  • paternally expressed 10
  • PEG10
  • Peg10
Epitope
AA 1-120
17
10
6
6
1
1
1
1
Reactivity
Human
110
26
17
7
6
4
3
2
2
1
Host
Mouse
69
41
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
6
6
4
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)
90
65
27
20
18
17
13
7
4
3
3
1
Options
Supplier
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Purpose Purified Mouse Monoclonal Antibody
Immunogen

Immunogen: Purified recombinant fragment of PEG10 (aa1-120) expressed in E. Coli.

Antigen Type: Recombinant Protein

Clone 1B1C4
Isotype IgG1
Characteristics Synonyms: Retrotransposon-derived protein PEG10, Embryonal carcinoma differentiation-regulated protein, Mammalian retrotransposon-derived protein 2, Myelin expression factor 3-like protein 1, MEF3-like protein 1, Paternally expressed gene 10 protein, Retrotransposon gag domain-containing protein 3, Retrotransposon-derived gag-like polyprotein, Ty3/Gypsy-like protein, PEG10, EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG3
Purification Ascitic fluid
Antigen
Alternative Name PEG10 (PEG10 Antibody Abstract)
Background

Other Names: Retrotransposon-derived protein PEG10, Embryonal carcinoma differentiation-regulated protein, Mammalian retrotransposon-derived protein 2, Myelin expression factor 3-like protein 1, MEF3-like protein 1, Paternally expressed gene 10 protein, Retrotransposon gag domain-containing protein 3, Retrotransposon-derived gag-like polyprotein, Ty3/Gypsy-like protein, PEG10, EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG3

Description: PEG10: paternally expressed 10. This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.

Molecular Weight 80173
Gene ID 23089
UniProt Q86TG7
Application Notes Western Bloting: = 1:500 - 2000, Immunofluorescence: = 1:200 - 1000.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Paternally Expressed 10 (PEG10) (AA 1-120) antibody (ABIN2869375) Figure 1: Western blot analysis using PEG10 mouse mAb against truncated Trx-PEG10 rec...
Immunohistochemistry (IHC) image for anti-Paternally Expressed 10 (PEG10) (AA 1-120) antibody (ABIN2869375) Figure 2: Immunohistochemical analysis of paraffin-embedded human Placenta tissues us...
Immunofluorescence (IF) image for anti-Paternally Expressed 10 (PEG10) (AA 1-120) antibody (ABIN2869375) Figure 3: Confocal immunofluorescence analysis of methanol-fixed HepG2 cells using PE...
Background publications Wang, Xiao, Hu, Chen, Liu, Hu: "PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma." in: FEBS letters, Vol. 582, Issue 18, pp. 2793-8, 2008 (PubMed).

Jie, Lang, Jian, Chaoqun, Dehua, Yi, Yanping, Luokun, Qiuping, Hui, Feili, Boquan, Youxin, Jinquan: "Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells." in: Oncogene, Vol. 26, Issue 39, pp. 5741-51, 2007 (PubMed).

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