TRPA1 antibody

Catalog No. ABIN290051

Product Details anti-TRPA1 Antibody

Target: TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purification: This antibody was established from the serum of a rabbit immunized with the partial peptide corresponding to amino acid 12-24 of mouse TRPA1, and purified by peptideaffinity chromatography.

Immunogen: Partial peptide of Mouse TRPA1

Application Details

Application Notes: Working dilution For Western blotting 1.6 ug/ml. For Immunoprecipitation 1.6 ug/ml

Restrictions: For Research Use only

Handling

Concentration: 0.25 mg/ml

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Preservative: ProClin

Storage: -20 °C

Target Details for TRPA1

Target: TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))

Alternative Name: TRPA1 (TRPA1 Products)

Synonyms: trpa1 antibody, ANKTM1 antibody, Anktm1 antibody, CG5751 antibody, CG5761 antibody, CT18073 antibody, DmTRPA1 antibody, Dmel\\CG5751 antibody, TRPA antibody, TRPA1 antibody, TrpA antibody, dANKTM1 antibody, dTRPA antibody, dTRPA1 antibody, dTrpA antibody, dTrpA1 antibody, dtrpA1 antibody, trpA1 antibody, GLEAN_02449 antibody, FEPS antibody, transient receptor potential cation channel, subfamily A, member 1a antibody, Transient receptor potential cation channel A1 antibody, transient receptor potential cation channel subfamily A member 1 antibody, transient receptor potential A1 antibody, tryptophan synthase subunit alpha 1 antibody, transient receptor potential cation channel, subfamily A, member 1 antibody, TRPA cation channel homolog antibody, trpa1a antibody, TrpA1 antibody, TRPA1 antibody, LOC658860 antibody, LOC694623 antibody, trpA1 antibody, trpa1 antibody, Trpa1 antibody, trpa-1 antibody

Background: Mammals feel a wide range of temperature spanning from cold to heat with specialized neurons in theperipheral nervous system. With this range, temperatures over about 43 degrees C and below about 15 degrees Cevoke not only a thermal sensation, but also a feeling of pain.Nine thermosensitive ion channels have been reported, all of which belong to TRP (transient receptorpotential) superfamily. They are expressed in sensory tissues, such as nociceptors and skin. Among them, TRPA1(TRP cation channel, subfamily A, member 1) has been identified as cold-sensitive ion channel. TRPA1 isactivated at approximately 17 degrees C, a temperature that is reported as painfully cold by humans.In addition to noxious cold, TRPA1 is activated pungent ingredients present in mustard, garlic, ginger, clove,wintergreen and cinnamon all and found in a subset of nociceptive sensory neurons where it is coexpressed withTRPV1/VR1 (capsaicin/heat receptor). Moreover, TRPA1 has been proposed to be a component of themechanosensitive transduction channel of vertebrate hair cells.This antibody will be very useful to research the nocifensive (thermosensitive and mechanosensitive) responseto pain.