Lamin B1 antibody (AA 397-586)

Catalog No. ABIN3015697

This Rabbit Polyclonal antibody specifically detects Lamin B1 in WB, IHC, IP and IF. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for Lamin B1 antibody (AA 397-586) (ABIN3015697)

Target: Lamin B1 (LMNB1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-Lamin B1 Antibody

Binding Specificity: AA 397-586

Sequence: RVTVSRASSS RSVRTTRGKR KRVDVEESEA SSSVSISHSA SATGNVCIEE IDVDGKFIRL KNTSEQDQPM GGWEMIRKIG DTSVSYKYTS RYVLKAGQTV TIWAANAGVT ASPPTDLIWK NQNSWGTGED VKVILKNSQG EEVAQRSTVF KTTIPEEEEE EEEAAGVVVE EELFHQQGTP RASNRSCAIM

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 397-586 of human Lamin B1 (NP_005564.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Lamin B1 antibody (ABIN3015697)

Cheng, Wei, Xie, Peng, Yan, Qin, Liu, Xu, Li, Zhang: "Alleviation of Toxicity Caused by Overactivation of Pparα through Pparα-Inducible miR-181a2." in: Molecular therapy. Nucleic acids, Vol. 9, pp. 195-206, (2017) (PubMed).

Ma, Fang, Luo, Yang, Wang, Zhang, Wang, Chen, Chan, Liu: "The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 4693703, (2017) (PubMed).

Target Details for Lamin B1

Target: Lamin B1 (LMNB1)

Alternative Name: LMNB1

Background: This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants.,ADLD,LMN,LMN2,LMNB,Lamin B1,LMNB1,lamin-B1,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Intermediate Filaments,LMNB1

Molecular Weight: 66 kDa

Gene ID: 4001

UniProt: P20700

Pathways: Apoptosis, Caspase Cascade in Apoptosis