TCL1A antibody (AA 1-114)

Catalog No. ABIN3021014

Product Details anti-TCL1A Antibody

Target: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Binding Specificity: AA 1-114

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCL1A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human TCL1A (NP_001092195.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TCL1A

Target: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Alternative Name: TCL1A (TCL1A Products)

Synonyms: TCL1A antibody, Tcl1a antibody, TCL1 antibody, Tcl1 antibody, T-cell leukemia/lymphoma 1A antibody, T cell lymphoma breakpoint 1 antibody, TCL1A antibody, Tcl1 antibody, Tcl1a antibody

Background: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],TCL1A,TCL1,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,TCL1A

Molecular Weight: 13 kDa

Gene ID: 8115

UniProt: P56279

Pathways: Stem Cell Maintenance