DPYD antibody (AA 1-173)

Catalog No. ABIN3022259

Product Details anti-DPYD Antibody

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Binding Specificity: AA 1-173

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYD antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAPVLSKDSA DIESILALNP RTQTHATLCS TSAKKLDKKH WKRNPDKNCF NCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI NIGGLQQFAT ETLILAFSLM NHL

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD (NP_001153773.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DPYD

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Alternative Name: DPYD (DPYD Products)

Background: The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.,DPYD,DHP,DHPDHASE,DPD,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,DPYD

Molecular Weight: 18 kDa/111 kDa

Gene ID: 1806

UniProt: Q12882

Pathways: Ribonucleoside Biosynthetic Process