Androgen Receptor antibody

Catalog No. ABIN3022797

This Rabbit Polyclonal antibody specifically detects Androgen Receptor in WB and IHC. It exhibits reactivity toward Human, Mouse and Ratand has been mentioned in 1 publication.

Quick Overview for Androgen Receptor antibody (ABIN3022797)

Target: Androgen Receptor (AR)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Androgen Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Androgen Receptor Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human AR

Isotype: IgG

Application Details

Application Notes: Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C/-80 °C

References for anti-Androgen Receptor antibody (ABIN3022797)

Xue, Zhang, Wang, Zhang, Xiang, Wang, Wang, Li, Zhang, Zou, Wang, Wu, Lu, Chen, Ding, Li, Xu: "Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer." in: European journal of medicinal chemistry, Vol. 152, pp. 542-559, (2018) (PubMed).

Target Details for Androgen Receptor

Target: Androgen Receptor (AR)

Alternative Name: AR

Background: Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding. This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. AR plays a crucial role in several stages of male development and the progression of prostate cancer.
Synonyms: KD, AIS, TFM, DHTR, SBMA, HYSP1, NR3C4, SMAX1, HUMARA

Gene ID: 367

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding