HDAC2 antibody (C-Term)

Catalog No. ABIN3022867

Product Details anti-HDAC2 Antibody

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Sequence: VHEDSGDEDG EDPDKRISIR ASDKRIACDE EFSDSEDEGE GGRRNVADHK KGAKKARIEE DKKETEDKKT DVKEEDKSKD NSGEKTDTKG TKSEQLSNP

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 390 to the C-terminus of human HDAC2 (NP_001518.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-HDAC2 antibody (ABIN3022867)

Fan, Li, Wang, Emerson, Xu: "A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer." in: Cancers, Vol. 13, Issue 15, (2021) (PubMed).

Wei, Liu, Chen, Gao, Lu, Zhang, Ding, Wang, Chen, Shi, Li, Yu, Wong: "Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription." in: Cell research, Vol. 27, Issue 7, pp. 898-915, (2018) (PubMed).

Li, Liu, He, Yang, Pei, Li, Liu, Chen, Xie, Xu, Ting, Zhang, Jin, Liu, Zhang, Yuan, Yang, Wu, Zhang, Yang, Yi, Liang, Shang, Sun: "ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin." in: Nature communications, Vol. 8, Issue 1, pp. 691, (2018) (PubMed).

Target Details for HDAC2

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Alternative Name: HDAC2 (HDAC2 Products)

Synonyms: HD2 antibody, RPD3 antibody, YAF1 antibody, D10Wsu179e antibody, Yy1bp antibody, mRPD3 antibody, HISTONE DEACETYLASE antibody, T1N24.9 antibody, T1N24_9 antibody, histone deacetylase 2 antibody, histone deacetylase 2 antibody, histone deacetylase 2 S homeolog antibody, HDAC2 antibody, Hdac2 antibody, hdac2.S antibody, HDA2 antibody

Background: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.,HD2,RPD3,YAF1,HDAC2,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Deacetylation,Nuclear Receptor Signaling,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,G1/S Checkpoint,Notch Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Stem Cells,Cardiovascular,Heart,Hypertrophy,HDAC2

Molecular Weight: 51 kDa/55 kDa

Gene ID: 3066

UniProt: Q92769

Pathways: Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection