UACA antibody
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- Target See all UACA Antibodies
- UACA
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Reactivity
- Human, Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This UACA antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Purification
- Protein G affinity chromatography
- Immunogen
- Nuclei of myeloid leukemia biopsy cells were used as the immunogen for the UACA antibody.
- Clone
- AE-5
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product UACA Primary Antibody
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- Application Notes
- Optimal dilution of the UACA antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Western blot: 0.5-1 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store the UACA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Target
- UACA
- Alternative Name
- UACA (UACA Products)
- Synonyms
- NUCLING antibody, 2700059D02Rik antibody, nucling antibody, RGD1560011 antibody, uveal autoantigen with coiled-coil domains and ankyrin repeats antibody, UACA antibody, Uaca antibody
- Background
- UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
- Pathways
- Positive Regulation of Endopeptidase Activity
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