DRAM antibody (N-Term)

Catalog No. ABIN3024191

Product Details anti-DRAM Antibody

Target: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRAM antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A affinity chromatography

Immunogen: A recombinant protein fragment from the N-terminal region of human DRAM was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.\. Western blot: 4-8 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DRAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for DRAM

Target: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Alternative Name: DRAM (DRAM1 Products)

Synonyms: DRAM1 antibody, DRAM antibody, 1200002N14Rik antibody, Dram antibody, dram antibody, DNA damage regulated autophagy modulator 1 antibody, DNA-damage regulated autophagy modulator 1 antibody, DNA damage regulated autophagy modulator 1 L homeolog antibody, DRAM1 antibody, Dram1 antibody, dram1.L antibody

Background: Autophagy is the mechanism by which lysosomes degrade unneeded or dysfunctional cellular components. p53 is a tumor suppressor protein that modulates autophagy and apoptosis. DRAM, or damage regulated autophagy modulator, is a lysosomal protein and effector of p53-mediated cell death. Many tumors show decreased DRAM expression and siRNA knockdown resulted in reduced cell death (Crighton et al, 2006).

Gene ID: 55332