Oxytocin Receptor antibody (C-Term)

Catalog No. ABIN302439

Product Details anti-Oxytocin Receptor Antibody

Target: Oxytocin Receptor (OXTR)

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Oxytocin Receptor antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects Oxytocin Receptor (OXTR), C-terminal cytoplasmic domain.

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide -KLH conjugated corresponding to C-terminal cytoplasmic domain of Human Oxytocin Receptor (OXTR).

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections (40 μg/mL). Antigen retrieval: Steam slides in 0.01M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for Oxytocin Receptor

Target: Oxytocin Receptor (OXTR)

Alternative Name: Oxytocin Receptor / OXTR (OXTR Products)

Synonyms: OXTR antibody, OT-R antibody, OTR antibody, OTR1 antibody, oxytocin receptor antibody, OXTR antibody, Oxtr antibody

Background: The oxytocin receptor belongs to the vasopressin/oxytocin family of GPCRs because it binds similar cyclic nonapeptide hormones. The oxytocin receptor functions primarily during labor and lactation. There is a dramatic increase in the number of oxytocin receptors just before the onset of labor causing the uterine muscles to become exceedingly sensitive to oxytocin. The activated oxytocin receptor causes an inward membrane current that results in smooth muscle contraction during labor and milk ejection during lactation. This receptor also plays a role in natriuresis, kaliuresis and may have an antistress effect.Synonyms: OT-R

Gene ID: 5021

NCBI Accession: NP_000907

UniProt: P30559

Pathways: Myometrial Relaxation and Contraction, Feeding Behaviour