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TAB3 antibody (N-Term)
TAB3
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TAB3 Antibody
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Target
See all TAB3 Antibodies
TAB3
(TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))
Binding Specificity
All epitopes for TAB3 antibodies
N-Term
Reactivity
All reactivities for TAB3 antibodies
Human, Mouse
Host
All hosts for TAB3 antibodies
Rabbit
Clonality
All clonalities for TAB3 antibodies
Polyclonal
Conjugate
All conjugates for TAB3 antibodies
This TAB3 antibody is un-conjugated
Application
All applications for TAB3 antibodies
Western Blotting (WB)
Purification
Protein A purified antibody
Immunogen
A recombinant protein fragment from the N-terminal region of human TAB3 was used as the immunogen for this antibody.
Isotype
IgG
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Discover our top product TAB3 Primary Antibody
Alternatives
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Application Details
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Application Notes
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.\. Western blot: 4-8 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the TAB3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for TAB3
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Target
TAB3
(TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))
Alternative Name
TAB3 (TAB3 Products )
Synonyms
MAP3K7IP3 antibody, NAP1 antibody, 4921526G09Rik antibody, Map3k7ip3 antibody, mKIAA4135 antibody, map3k7ip3 antibody, nap1 antibody, tab3 antibody, tab3-a antibody, tab3-b antibody, map3k7ip3l antibody, si:ch211-232d19.8 antibody, si:dkey-30h22.6 antibody, TGF-beta activated kinase 1 and MAP3K7 binding protein 3 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 3 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 3 S homeolog antibody, TAB3 antibody, Tab3 antibody, tab3.S antibody, tab3 antibody
Background
TAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs). TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.
Gene ID
257397
Pathways
TLR Signaling , Fc-epsilon Receptor Signaling Pathway , Activation of Innate immune Response , Toll-Like Receptors Cascades
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