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MUC1 antibody

MUC1 Reactivity: Human IHC (p) Host: Mouse Monoclonal MUC1-845 unconjugated
Catalog No. ABIN3026735
  • Target See all MUC1 Antibodies
    MUC1 (Mucin 1 (MUC1))
    Reactivity
    • 272
    • 58
    • 30
    • 12
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 198
    • 87
    • 2
    • 1
    Mouse
    Clonality
    • 176
    • 107
    • 5
    Monoclonal
    Conjugate
    • 147
    • 26
    • 16
    • 11
    • 11
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MUC1 antibody is un-conjugated
    Application
    • 141
    • 137
    • 103
    • 84
    • 75
    • 48
    • 26
    • 24
    • 24
    • 20
    • 19
    • 14
    • 13
    • 13
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Characteristics
    This antibody recognizes proteins in MW range of 265-400 kDa, identified as different glycoforms of MUC1 (Mucin-1) or EMA (epithelial membrane antigen). The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. MUC1 / Mucin-1 may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling through phosphorylations and protein-protein interactions. In immunohistochemical assays, the MUC1 / EMA antibody superbly stains routine formalin/paraffin carcinoma tissues. MUC1 antibody is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
    Purification
    Protein G affinity chromatography
    Purity
    Protein G affinity chromatography
    Immunogen
    Human milk fat globule membranes were used as the immunogen for this EMA antibody.
    Clone
    MUC1-845
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product MUC1 Primary Antibody
  • Application Notes
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the EMA antibody to be titered up or down for optimal performance.

    1. No pretreatment needed for FFPE staining.
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Prediluted IHC only format : incubate for 30 min at RT (2)

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, *For IHC use only*
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store the EMA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    MUC1 (Mucin 1 (MUC1))
    Alternative Name
    EMA (MUC1 Products)
    Synonyms
    CA 15-3 antibody, CD227 antibody, EMA antibody, H23AG antibody, KL-6 antibody, MAM6 antibody, MCKD1 antibody, MUC-1 antibody, MUC-1/SEC antibody, MUC-1/X antibody, MUC1/ZD antibody, PEM antibody, PEMT antibody, PUM antibody, Muc-1 antibody, mucin 1, cell surface associated antibody, mucin 1, transmembrane antibody, MUC1 antibody, Muc1 antibody
    Background
    This antibody recognizes proteins in MW range of 265-400  kDa, identified as different glycoforms of MUC1 (Mucin-1) or EMA (epithelial membrane antigen). The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. MUC1 / Mucin-1 may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling through phosphorylations and protein-protein interactions. In immunohistochemical assays, the MUC1 / EMA antibody superbly stains routine formalin/paraffin carcinoma tissues. MUC1 antibody is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
    Gene ID
    4582
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
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