TIA1 antibody (N-Term)

Catalog No. ABIN3029129

Product Details anti-TIA1 Antibody

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIA1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human TIA1 (STQRSQDHFHVFV) was used as the immunogen for this TIA-1 antibody (100% mouse homology).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the TIA-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the TIA-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for TIA1

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Alternative Name: TIA-1 (TIA1 Products)

Synonyms: tia1 antibody, 2310050N03Rik antibody, AI256674 antibody, TIA-1 antibody, mTIA-1 antibody, WDM antibody, TIAL1 antibody, TIAR antibody, tia-1 antibody, nucleolysin TIA-1 isoform p40 antibody, hypothetical protein antibody, nucleolysin TIAR antibody, nucleolysin tia-1 antibody, nucleolysin TIA-1 antibody, cytotoxic granule-associated RNA binding protein 1 antibody, TIA1 cytotoxic granule associated RNA binding protein antibody, TIA1 cytotoxic granule-associated RNA binding protein antibody, TIA1 cytotoxic granule-associated RNA binding protein L homeolog antibody, PTRG_10065 antibody, PGTG_08590 antibody, LOC5568274 antibody, CpipJ_CPIJ013665 antibody, VDBG_07004 antibody, MGYG_03339 antibody, Tsp_15456 antibody, tia1 antibody, Tia1 antibody, TIA1 antibody, tia1.L antibody

Background: TIA-1 (T-Cell Intracellular Antigen-1), also called WDM, is an RNA-binding protein involved in splicing regulation and translational repression. It is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte(CTL) target cells. By in situ hybridization, the gene is mapped to chromosome 2p13.3. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is though to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing.

UniProt: P31483