CSF3R antibody (Middle Region)

Catalog No. ABIN3029704

Product Details anti-CSF3R Antibody

Target: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSF3R antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human CSF3R (EPWQPGLHINQKCELRHK) was used as the immunogen for this CSF3R antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the CSF3R antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CSF3R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CSF3R

Target: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Alternative Name: CSF3R Colony Stimulating Factor 3 Receptor (CSF3R Products)

Synonyms: CD114 antibody, GCSFR antibody, Cd114 antibody, Csfgr antibody, G-CSF-R antibody, G-CSFR antibody, CSF3R antibody, gcsfr antibody, cd114 antibody, colony stimulating factor 3 receptor antibody, colony stimulating factor 3 receptor (granulocyte) antibody, colony stimulating factor 3 receptor L homeolog antibody, granulocyte colony-stimulating factor receptor antibody, CSF3R antibody, Csf3r antibody, csf3r antibody, csf3r.L antibody, LOC100433338 antibody

Background: Colony-Stimulating Factor 3 Receptor, Granulocyte also known as GCSFR or CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

UniProt: Q99062