SOD2 antibody (N-Term)

Catalog No. ABIN3029761

Product Details anti-SOD2 Antibody

Target: SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human SOD2 (QIMQLHHSKHHAAYVNNL) was used as the immunogen for this SOD2 antibody (100% mouse homology).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the SOD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SOD2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for SOD2

Target: SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))

Alternative Name: SOD2 Superoxide Dismutase 2 (SOD2 Products)

Synonyms: LOC100101896 antibody, MNSOD antibody, GB14346 antibody, sod2 antibody, MGC88869 antibody, Sod2 antibody, CG8905 antibody, Dmel\\CG8905 antibody, Mito SOD antibody, Mn SOD antibody, Mn-SOD antibody, Mn-SOD2 antibody, MnSOD antibody, MnSODII antibody, Mn[2+]SOD antibody, SOD antibody, SOD-2 antibody, SOD2 antibody, Sod-2 antibody, dSOD2 antibody, mitSOD2 antibody, mnSOD antibody, IPOB antibody, MVCD6 antibody, cb463 antibody, wu:fj33b01 antibody, zgc:73051 antibody, MnSOD antibody, manganese superoxide dismutase antibody, superoxide dismutase 2, mitochondrial antibody, superoxide dismutase 2 antibody, Mn superoxide dismutase antibody, Superoxide dismutase 2 (Mn) antibody, superoxide dismutase 2 L homeolog antibody, BDBG_07234 antibody, LOC100101896 antibody, MNSOD antibody, Sod2 antibody, sod2 antibody, LbMnSOD4 antibody, SOD2 antibody, LOC100282741 antibody, SOD-2 antibody, sod2.L antibody

Background: Superoxide Dismutase 2, also called IPO-B or MNSOD, is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions occurring in mitochondria. This gene is a member of the iron/manganese superoxide dismutase family. Using a somatic cell hybrid panel containing different segments of chromosome 6, they demonstrated that SOD2 is located in the region 6q25.3-qter which, together with the FISH analysis, indicated that the enzyme is in the distal portion of 6q25. The gene encodes an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation. Adeno-associated viral delivery of the human gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion cells. The findings suggested that reactive oxygen species contributed to retinal cell death and optic nerve damage in mice with complex I deficiency, and that expression of SOD2 attenuated the disease process.

UniProt: P04179

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Negative Regulation of intrinsic apoptotic Signaling