Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

AIM2 antibody (Absent in Melanoma 2) (AA 1-50) Primary Antibody

AIM2 Reactivity: Human FACS, IF, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3029828
$493.63
Plus shipping costs $45.00
0.4 mL ABIN3029828
0.4 mL ABIN3029828
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days
  • Target
    AIM2
    Binding Specificity
    AA 1-50
    • 15
    • 12
    • 8
    • 8
    • 8
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human
    • 84
    • 26
    • 20
    • 3
    • 3
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This AIM2 antibody is un-conjugated
    • 46
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Western Blotting (WB)
    • 66
    • 45
    • 26
    • 22
    • 19
    • 13
    • 13
    • 6
    • 5
    • 3
    • 2
    • 1
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 1-50 from the human protein was used as the immunogen for this AIM2 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the AIM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the AIM2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    AIM2
    Alternative Name
    AIM2 (AIM2 Antibody Abstract)
    Synonyms
    AIM2, PYHIN4, Gm1313, Ifi210, absent in melanoma 2, AIM2, Aim2
    Background
    Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. [UniProt]
    UniProt
    O14862
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
You are here:
help Support