ASIC3 antibody (N-Term)

Catalog No. ABIN3029921

Product Details anti-ASIC3 Antibody

Target: ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASIC3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human Acid-Sensing Ion Channel 3 (FLYQVAERVRYYREFHHQ) was used as the immunogen for this ASIC3 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the ASIC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the ASIC3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for ASIC3

Target: ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))

Alternative Name: ASIC3 (ACCN3 Products)

Synonyms: ACCN3 antibody, Accn3 antibody, DRASIC antibody, SLNAC1 antibody, TNaC1 antibody, AW742291 antibody, TNAC1 antibody, amiloride-sensitive cation channel 3 antibody, acid sensing ion channel subunit 3 antibody, acid-sensing (proton-gated) ion channel 3 antibody, ACCN3 antibody, ASIC3 antibody, Asic3 antibody

Background: Acid-Sensing Ion Channel 3, also known as Testis sodium channel (TNAC1) or Dorsal root acid-sensing ion channel (DRASIC), is a protein that in humans is encoded by the ASIC3 gene. ASIC3 belongs to a family of acid-sensing channel proteins that are structurally related to epithelial sodium channel proteins and support acid-activated membrane currents. By radiation hybrid analysis, de Weille et al.(1998) mapped the gene to chromosome 7q35. De Weille et al.(1998) found that the human protein supported an H(+)-gated cation current in COS cells with kinetics similar to those of the rat protein. Babinski et al. (1999) expressed homomeric human ASIC3 channels in Xenopus oocytes and found that rapid reduction in extracellular pH resulted in a biphasic response characterized by a fast and rapidly desensitizing current followed by a slow and sustained current that returned to baseline only on return to physiologic pH .

UniProt: Q9UHC3