ABCC4 antibody (AA 1-370)

Catalog No. ABIN3030055

Product Details anti-ABCC4 Antibody

Target: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Binding Specificity: AA 1-370

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 1-370) was used as the immunogen for this MRP4 antibody.

Isotype: IgG

Application Details

Application Notes: Titration of the MRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: The lyophilized MRP4 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for ABCC4

Target: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Alternative Name: MRP4 (ABCC4 Products)

Synonyms: EST170205 antibody, MOAT-B antibody, MOATB antibody, MRP4 antibody, D630049P08Rik antibody, Mrp4 antibody, ATP binding cassette subfamily C member 4 antibody, multidrug resistance-associated protein 4 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 4 antibody, ABCC4 antibody, LOC515333 antibody, LOC616707 antibody, LOC695407 antibody, abcc4 antibody, Abcc4 antibody

Background: ABCC4 (ATP-binding cassette, subfamily c, member 4) also known as MRP4 (Multidrug resistance associated protein 4) or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4/MRP4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of MPR4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of its activity or knockdown of the protein via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that MRP4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Gene ID: 10257