CXCL1 antibody (C-Term)

Catalog No. ABIN3030502

Product Details anti-CXCL1 Antibody

Target: CXCL1 (Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCL1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human GROA (KMLNSDKSN) was used as the immunogen for this GRO alpha antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the GRO alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the GRO alpha antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CXCL1

Target: CXCL1 (Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1))

Alternative Name: GRO alpha (CXCL1 Products)

Synonyms: FSP antibody, GRO1 antibody, GROa antibody, MGSA antibody, MGSA-a antibody, NAP-3 antibody, SCYB1 antibody, CINC-1 antibody, Gro1 antibody, CXCL1 antibody, Sdf1 antibody, Fsp antibody, KC antibody, Mgsa antibody, N51 antibody, Scyb1 antibody, gro antibody, GRO antibody, Gro antibody, C-X-C motif chemokine ligand 1 antibody, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) antibody, C-X-C motif chemokine ligand 12 antibody, chemokine (C-X-C motif) ligand 1 antibody, CXCL1 antibody, Cxcl1 antibody, Cxcl12 antibody, GRO1 antibody

Background: CXCL1 (Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO alpha, KC, Neutrophil-activating protein 3(NAP-3) and melanoma growth stimulating activity, alpha (MSGA-alpha). In humans, this protein is encoded by the CXCL1 gene. It is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. It is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1/GROA plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis. Signaling through CXCR2, CXCL1/GROA inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions.

UniProt: P09341

Pathways: Autophagy