COL4A1 antibody (C-Term)

Catalog No. ABIN3030546

Product Details anti-COL4A1 Antibody

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL4A1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human Collagen IV COL4A1 (ELRTHVSRCQVCMRRT) was used as the immunogen for this Collagen IV antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Collagen IV antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Collagen IV antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for COL4A1

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Alternative Name: Collagen IV (COL4A1) (COL4A1 Products)

Synonyms: col4a1 antibody, wu:fc02g11 antibody, HANAC antibody, ICH antibody, POREN1 antibody, arresten antibody, Bru antibody, Col4a-1 antibody, Del(8)44H antibody, Raw antibody, Svc antibody, collagen, type IV, alpha 5 (Alport syndrome) antibody, collagen type IV alpha 1 chain antibody, collagen, type IV, alpha 1 antibody, col4a5 antibody, COL4A1 antibody, Col4a1 antibody

Background: Collagen alpha-1(IV) chain is a protein that in humans is encoded by the COL4A1 gene. Type IV collagen is the major structural component of glomerular basement membranes(GBM), forming a'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in COL4A1 exons 24 and 25 are associated with HANAC(autosomal dominant hereditary angiopathy with nephropathy,aneurysms, and muscle cramps).

UniProt: P02462

Pathways: Skeletal Muscle Fiber Development, Growth Factor Binding