COL4A1 antibody (AA 1445-1669)

Catalog No. ABIN3030553

Product Details anti-COL4A1 Antibody

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Binding Specificity: AA 1445-1669

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL4A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 1445-1669) was used as the immunogen for this Collagen IV antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Collagen IV antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Collagen IV antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for COL4A1

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Alternative Name: Collagen IV / COL4A1 (COL4A1 Products)

Synonyms: col4a1 antibody, wu:fc02g11 antibody, HANAC antibody, ICH antibody, POREN1 antibody, arresten antibody, Bru antibody, Col4a-1 antibody, Del(8)44H antibody, Raw antibody, Svc antibody, collagen, type IV, alpha 5 (Alport syndrome) antibody, collagen type IV alpha 1 chain antibody, collagen, type IV, alpha 1 antibody, col4a5 antibody, COL4A1 antibody, Col4a1 antibody

Background: COL4A1, also known as ICH or Collagen alpha-1(IV), is a protein that in humans is encoded by the COL4A1 gene. It is mapped to 13q34. This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. COL4A1 binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. It is also a potential therapeutic candidate for targeting tumor angiogenesis.

Gene ID: 1282

Pathways: Skeletal Muscle Fiber Development, Growth Factor Binding