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CRTC2 antibody (C-Term)

CRTC2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3030573
  • Target See all CRTC2 Antibodies
    CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
    Binding Specificity
    • 16
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 67
    • 22
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 59
    • 6
    • 4
    • 1
    Rabbit
    Clonality
    • 63
    • 7
    Polyclonal
    Conjugate
    • 30
    • 7
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CRTC2 antibody is un-conjugated
    Application
    • 62
    • 43
    • 19
    • 17
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogen
    An amino acid sequence from the C-terminus of human CRTC2 (QDPHTFNHQNLTHCSRH) was used as the immunogen for this CRTC2 antibody.
    Isotype
    IgG
    Top Product
    Discover our top product CRTC2 Primary Antibody
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the CRTC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the CRTC2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
    Alternative Name
    CRTC2 (CRTC2 Products)
    Synonyms
    CRTC2 antibody, TORC-2 antibody, TORC2 antibody, 4632407F12Rik antibody, Torc2 antibody, mTORC2 antibody, RGD1308903 antibody, CREB regulated transcription coactivator 2 antibody, CRTC2 antibody, Crtc2 antibody
    Background
    CREB-Regulated Transcription Coactivator 2, also known as TORC2, is a protein that in humans is encoded by the CRTC2 gene. The International Radiation Hybrid Mapping Consortium mapped the gene to chromosome 1. By cotransfection of TORC2 and reporter genes in HeLa cells, Iourgenko et al.(2003) found that it potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences. Liu et al.(2008) demonstrated that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin-1(SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1. Using mice and primary mouse hepatocytes, Wang et al.(2009) found that the protein functioned as a dual sensor for endoplasmic reticulum(ER) stress and fasting signals.
    UniProt
    Q53ET0
    Pathways
    AMPK Signaling, Carbohydrate Homeostasis
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