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CDK5 antibody (Cyclin-Dependent Kinase 5) (AA 254-289) Primary Antibody

CDK5 Reactivity: Human, Mouse FACS, IF, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3030614
$507.38
Plus shipping costs $45.00
0.4 mL ABIN3030614
0.4 mL ABIN3030614
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  • Target
    CDK5
    Binding Specificity
    AA 254-289
    • 22
    • 15
    • 15
    • 14
    • 9
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human, Mouse
    • 159
    • 112
    • 101
    • 18
    • 15
    • 15
    • 15
    • 14
    • 13
    • 12
    • 9
    • 9
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This CDK5 antibody is un-conjugated
    • 99
    • 11
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Application
    Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Western Blotting (WB)
    • 117
    • 54
    • 27
    • 27
    • 22
    • 21
    • 19
    • 14
    • 13
    • 4
    • 3
    • 3
    • 1
    Cross-Reactivity (Details)
    Expected species reactivity: Rat, Bovine, Xenopus
    Purification
    Antigen affinity purified
    Immunogen
    This CDK5 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 254-289 amino acids from the C-terminal region of human CDK5.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the CDK5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:25,Immunofluorescence: 1:25,Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the CDK5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    CDK5
    Alternative Name
    CDK5 (CDK5 Antibody Abstract)
    Synonyms
    PSSALRE, AW048668, Crk6, CDK5, CG8203, DmCdk5, Dmel\\CG8203, cdk5, zgc:101604, cyclin dependent kinase 5, cyclin-dependent kinase 5, Cyclin-dependent kinase 5, cyclin-dependent kinase 5 L homeolog, Cyclin-dependent-like kinase 5, CDK5, Cdk5, cdk5, cdk5.L, cdk-5
    Background
    Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity, synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity.[UniProt]
    UniProt
    Q00535
    Pathways
    Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
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