An amino acid sequence from the N-terminus of human Early growth response protein 2 (TMSQTQPDLDHLYSPP) was used as the immunogen for this EGR2 antibody.
EGR2
Reactivity: Human
WB, IF
Host: Mouse
Monoclonal
1F10
unconjugated
Application Notes
The stated application concentrations are suggested starting amounts. Titration of the EGR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Storage
-20 °C
Storage Comment
After reconstitution, the EGR2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. This gene is mapped to 10q21.3. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D(CMT1D), Charcot-Marie-Tooth disease type 4E(CMT4E), and with Dejerine-Sottas syndrome(DSS). EGR2 assists with SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.