EIF2S1 antibody (Middle Region)

Catalog No. ABIN3030881

Product Details anti-EIF2S1 Antibody

Target: EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF2S1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human Eukaryotic Translation Initiation Factor 2 subunit 1 (KDEQLESLFQRTAWV) was used as the immunogen for this EIF2A antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the EIF2S1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the EIF2S1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for EIF2S1

Target: EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

Alternative Name: EIF2S1 (EIF2S1 Products)

Synonyms: EIF-2 antibody, EIF-2A antibody, EIF-2alpha antibody, EIF2 antibody, EIF2A antibody, Eif2s1 antibody, eif2s1l antibody, fb36a08 antibody, wu:fb36a08 antibody, zgc:56510 antibody, 0910001O23Rik antibody, 2410026C18Rik antibody, 35kDa antibody, Eif2a antibody, eIF2alpha antibody, eif2a antibody, CG9946 antibody, Dmel\\CG9946 antibody, Eif2alpha antibody, IF2A_DROME antibody, M(1)14C antibody, M(1)19-153 antibody, M(1)8e3-10 antibody, deIF2alpha antibody, eIF-2 antibody, eIF-2 a antibody, eIF-2 alpha antibody, eIF2 alpha antibody, eIF2-alpha antibody, eIF2a antibody, eiF-2alpha antibody, elF2alpha antibody, l(1)14Cf antibody, l(1)19-153 antibody, eukaryotic translation initiation factor 2 subunit alpha antibody, eukaryotic translation initiation factor 2, subunit 1 alpha a antibody, eukaryotic translation initiation factor 2, subunit 1 alpha antibody, eukaryotic translation initiation factor 2 alpha subunit antibody, Eukaryotic translation initiation factor 2 subunit 1 antibody, eukaryotic translation initiation factor 2 subunit alpha L homeolog antibody, eukaryotic translation Initiation Factor 2alpha antibody, EIF2S1 antibody, eif2s1a antibody, Eif2s1 antibody, eif2s1 antibody, LOC693063 antibody, CNI00230 antibody, THAPSDRAFT_105 antibody, if2a antibody, eif2s1.L antibody, eIF-2alpha antibody

Background: Eukaryotic Translation Initiation Factor 2, Subunit 1, also called EIF2-alpha or EIF2A, is a protein that in humans is encoded by the EIF2S1 gene. Hartz(2010) mapped the gene to chromosome 14q23.3 based on an alignment of the EIF2S1 sequence with the genomic sequence (GRCh37). Ernst et al.(1987) stated that protein synthesis is inhibited due to phosphorylation of EIF2S1 in hemin-deprived rabbit reticulocyte lysates. HeLa cells subjected to heat shock, serum deprivation, or interferon treatment followed by virus infection also show a correlation between EIF2S1 phosphorylation and translational repression. Jacob et al.(1989) found that the alpha-Pal transcription factor bound to two palindromic sites within the EIF2S1 promoter and was essential for transcription of the gene.

UniProt: P05198

Pathways: Ribonucleoprotein Complex Subunit Organization, ER-Nucleus Signaling, Hepatitis C