FER antibody (Middle Region)

Catalog No. ABIN3030923

Product Details anti-FER Antibody

Target: FER (FER Tyrosine Kinase (FER))

Binding Specificity: Middle Region

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FER antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human FER (FSNIPQLIDHHYTTKQ) was used as the immunogen for this FER antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the FER antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the FER antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for FER

Target: FER (FER Tyrosine Kinase (FER))

Alternative Name: FER (FER Products)

Synonyms: FerT antibody, PPP1R74 antibody, TYK3 antibody, Fer antibody, Flk antibody, Flk_retired antibody, AV082135 antibody, C330004K01Rik antibody, Fert antibody, FER tyrosine kinase antibody, fer (fms/fps related) protein kinase antibody, FER antibody, Fer antibody

Background: FPS/FES-Related tyrosine kinase, also known as TYK3, is an enzyme that in humans is encoded by the FER gene. FER protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al.(1990) concluded that the gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that the protein mediates crosstalk between CDH2 and ITGB1. In FER mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that the protein has a role in regulating innate immunity.

UniProt: P16591