Hepsin antibody (C-Term)

Catalog No. ABIN3031191

Product Details anti-Hepsin Antibody

Target: Hepsin (HPN)

Binding Specificity: C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hepsin antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human Hepsin (KVSDFREWIFQAIKTHSEA) was used as the immunogen for this Hepsin antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Hepsin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Hepsin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Hepsin

Target: Hepsin (HPN)

Alternative Name: Hepsin (HPN Products)

Synonyms: TMPRSS1 antibody, Hlb320 antibody, hepsin antibody, si:dkey-33i11.3 antibody, HPN antibody, si:dkey-33i11.3 antibody, Hpn antibody

Background: Hepsin, also known as TMPRSS1, is an enzyme that in humans is encoded by the HPN gene. Tsuji et al.(1991) mapped the gene to 19q11-q13.2. Using cDNA microarrays, Dhanasekaran et al.(2001) examined gene expression profiles of more than 50 normal and neoplastic prostate specimens and 3 common prostate cancer cell lines. Signature expression profiles of normal adjacent prostate, benign prostatic hypertrophy, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. In 3 different human cell lines, Guipponi et al.(2008) found that Hepsin was stably anchored in the endoplasmic reticulum.

UniProt: P05981

Pathways: Regulation of Hormone Metabolic Process, Sensory Perception of Sound