HIF3A antibody (C-Term)

Catalog No. ABIN3031285

Product Details anti-HIF3A Antibody

Target: HIF3A (Hypoxia Inducible Factor 3, alpha Subunit (HIF3A))

Binding Specificity: C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIF3A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human HIF3A (DDDFQLNASEQLPRAYHR) was used as the immunogen for this HIF-3 alpha antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the HIF-3 alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the HIF-3 alpha antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for HIF3A

Target: HIF3A (Hypoxia Inducible Factor 3, alpha Subunit (HIF3A))

Alternative Name: HIF-3 alpha (HIF3A Products)

Background: Hypoxia-inducible factor 3 alpha, also called MOP7, is a protein that in humans is encoded by the HIF3A gene. This gene involved in adaptive response to hypoxia. HIF3a suppresses hypoxia-inducible expression of < a href=../search_result.php?search_txt=hif1a>HIF1a and < a href=../search_result.php?search_txt=hif2a>HIF2a. It binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element(HRE) of target gene promoters. The complex HIF3a-ARNT activates the transcription of reporter genes driven by HRE. This gene functions as an inhibitor of angiogenesis in the cornea.

UniProt: Q9Y2N7

Pathways: Warburg Effect