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LRRK2 antibody (Leucine-Rich Repeat Kinase 2) (C-Term) Primary Antibody

LRRK2 Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031608
$507.38
Plus shipping costs $45.00
0.4 mL ABIN3031608
0.4 mL ABIN3031608
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  • Target
    LRRK2
    Binding Specificity
    • 4
    • 2
    • 2
    • 2
    • 1
    C-Term
    Reactivity
    • 10
    • 7
    Human
    Host
    • 7
    • 3
    Rabbit
    Clonality
    • 7
    • 3
    Polyclonal
    Application
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    This LRRK2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 2171-2207 amino acids from the C-terminal region of human LRRK2.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the LRRK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the LRRK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    LRRK2
    Alternative Name
    LRRK2 (LRRK2 Antibody Abstract)
    Synonyms
    LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, 4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46, leucine-rich repeat kinase 2, leucine rich repeat kinase 2, lrrk2, LRRK2, Lrrk2
    Background
    Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH , and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (,CNS),. Phosphorylates PRDX3. May also have GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
    UniProt
    Q5S007
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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