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LRRK2 antibody (Leucine-Rich Repeat Kinase 2) (AA 930-961) Primary Antibody

LRRK2 Reactivity: Human, Mouse IF, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031610
$507.38
Plus shipping costs $45.00
0.4 mL ABIN3031610
0.4 mL ABIN3031610
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  • Target
    LRRK2
    Binding Specificity
    • 5
    • 2
    • 2
    • 1
    • 1
    AA 930-961
    Reactivity
    Human, Mouse
    Host
    • 7
    • 3
    Rabbit
    Clonality
    • 7
    • 3
    Polyclonal
    Application
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF), ELISA, Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 930-961 from the human protein was used as the immunogen for this PARK8 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the PARK8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the PARK8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    LRRK2
    Alternative Name
    PARK8 (LRRK2 Antibody Abstract)
    Synonyms
    LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, 4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46, leucine-rich repeat kinase 2, leucine rich repeat kinase 2, lrrk2, LRRK2, Lrrk2
    Background
    Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2/PARK8, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. PARK8 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
    UniProt
    Q5S007
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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