MCM6 antibody (Middle Region)

Catalog No. ABIN3031807

Product Details anti-MCM6 Antibody

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human MCM6 (ESEDFIVEQYKHLRQRD) was used as the immunogen for this MCM6 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the MCM6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the MCM6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for MCM6

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Alternative Name: MCM6 (MCM6 Products)

Synonyms: CG4039 antibody, DmMCM6 antibody, DmeMCM6 antibody, Dmel\\CG4039 antibody, MCM6 antibody, McM6 antibody, fs(1)K1214 antibody, mcm6 antibody, MCG40308 antibody, Mis5 antibody, P105MCM antibody, Mcmd6 antibody, mis5 antibody, mmcm6 antibody, ASP-l1 antibody, D1Wsu22e antibody, Minichromosome maintenance 6 antibody, DNA replication licensing factor MCM6 antibody, minichromosome maintenance complex component 6 antibody, minichromosome maintenance complex component 6 L homeolog antibody, DNA replication licensing factor mcm-6 antibody, Mcm6 antibody, TP02_0113 antibody, PVX_114735 antibody, CMU_027970 antibody, MCM6 antibody, mcm6.L antibody, mcm-6 antibody

Background: Minichromosome maintenance, s. pombe, homolog of, 6 is a protein that in humans is encoded by the MCM6 gene. It is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The MCM genes were originally identified in yeast defective in minichromosome maintenance and have since been shown to play roles in the progression of the cell cycle, many are cell division control genes. MCM6 has recently been shown to interact strongly Cdt1 at defined residues by mutating these target residues. Wei et al. observed lack of Cdt1 recruitment of MCM2-7 to the pre-RC. An approximately 200-kb region surrounding the C/T(-13910) polymorphism in MCM6 intron 13 functioned as an enhancer of the lactase gene promoter in intestinal cell culture.

UniProt: Q14566

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA