PER2 antibody (AA 13-330)

Catalog No. ABIN3032182

Product Details anti-PER2 Antibody

Target: PER2 (Period Circadian Protein 2 (PER2))

Binding Specificity: AA 13-330

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PER2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 13-330) was used as the immunogen for this PER2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the PER2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the PER2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for PER2

Target: PER2 (Period Circadian Protein 2 (PER2))

Alternative Name: PER2 (PER2 Products)

Synonyms: FASPS antibody, FASPS1 antibody, mKIAA0347 antibody, mPer2 antibody, rPER2 antibody, gPer2 antibody, fj43b09 antibody, wu:fj43b09 antibody, period circadian regulator 2 antibody, period circadian clock 2 antibody, PER2 antibody, Per2 antibody, per2 antibody

Background: Period circadian protein homolog 2 is a member of the Period family of proteins and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. It is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. The protein also functions in tumor suppression by regulating DNA damage-responsive pathways.

Gene ID: 8864